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Poly-D-lysine hydrobromide (MW 30000-70000)

CAS No. 27964-99-4

Poly-D-lysine hydrobromide (MW 30000-70000)( —— )

Catalog No. M35204 CAS No. 27964-99-4

Poly-D-lysine hydrobromide (MW 30000-70000) (Poly-D-lysine HBr) is an oral peptide CaSR agonist that eliminates proteinase K-resistant PrP from prion-infected SN56 neuroblastoma cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Poly-D-lysine hydrobromide (MW 30000-70000)
  • Note
    Research use only, not for human use.
  • Brief Description
    Poly-D-lysine hydrobromide (MW 30000-70000) (Poly-D-lysine HBr) is an oral peptide CaSR agonist that eliminates proteinase K-resistant PrP from prion-infected SN56 neuroblastoma cells.
  • Description
    Poly-D-lysine hydrobromide (MW 30000-70000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide (MW 30000-70000) removes proteinase K-resistant PrP from prion-infected SN56 neuroblastoma cells without affecting PrPC.
  • In Vitro
    Poly-D-lysine is immunogenic in rabbits only when injected at low doses.The approximate concentration of Poly-D-lysine (PDL) needed to lower the amount of PrPres by 50% corresponds to ~0.8 μg/mL or 50 nM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    CaSR
  • Recptor
    CaSR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    27964-99-4
  • Formula Weight
  • Molecular Formula
    (C6H14N2O2)x.xHBr
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 50 mg/mL (Ultrasonic))
  • SMILES
    (C6H14N2O2)x.xHBr
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. HansVermeersch, et al. Immunogenicity of poly-D-lysine, a potential polymeric drug carrier. Journal of Controlled Release. Volume 32, Issue 3, 1 December 1994, Pages 225-229.
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